What is CJC-1295?
CJC-1295 is a synthetic growth hormone-releasing hormone analogue. The original clinical-development molecule included a Drug Affinity Complex that allowed it to bind albumin and remain in circulation for several days.
What is the difference between CJC-1295 with DAC and without DAC?
The DAC form adds an albumin-binding C-terminal modification to the 29-amino-acid GHRH analogue. The published human half-life and GH/IGF-1 studies used the DAC active moiety. FDA did not identify a comparable direct clinical evidence base for the non-DAC free-base form.
What benefits of CJC-1295 are actually proven in humans?
Human studies show that CJC-1295 DAC can raise circulating growth hormone and IGF-1 for several days. They do not establish muscle gain, fat loss, improved recovery, better sleep or anti-ageing outcomes.
What is the half-life of CJC-1295?
For the DAC clinical material, the published single-dose estimate was about 5.8–8.1 days, with FDA's repeated-dose reconstruction reporting about 5.4–9.2 days. A validated human half-life for the non-DAC form was not established in the evidence reviewed.
What doses of CJC-1295 have been studied?
Historical human CJC-1295 DAC studies used weight-based subcutaneous research protocols ranging from 20 to 250 micrograms/kg depending on the study and schedule. These are trial methods, not personal dosing instructions, and they do not establish a human protocol for no-DAC products.
What side effects were reported with CJC-1295?
Early DAC studies reported frequent injection-site reactions, headache, diarrhoea, flushing, warmth, transient hypotension and dose-related increases in heart rate. The studies were small and short, so reliable long-term frequencies are not established.
Did CJC-1295 increase growth hormone without removing normal pulses?
In a 12-man study, one dose increased trough and mean growth hormone and IGF-1 while pulse frequency and pulse magnitude remained broadly unchanged one week later.
Does CJC-1295 build muscle or reduce fat?
The published healthy-volunteer studies did not measure lean-mass gain or fat loss. A Phase 2 trial in HIV-associated visceral obesity was terminated and never posted efficacy results, so those outcome claims are not established.
Has CJC-1295 been studied with ipamorelin?
No interventional human study administering CJC-1295 and ipamorelin together was identified in the searches run for this handoff. The two compounds have separate mechanisms and separate human research records.
Why was the CJC-1295 Phase 2 trial terminated?
The HIV-associated visceral-obesity trial was halted after a participant had an acute myocardial infarction and died after the eleventh weekly dose. FDA's later review reports that the treating physician considered previously asymptomatic coronary artery disease with plaque rupture the most likely explanation. Causality from CJC-1295 was not established.
Is CJC-1295 banned in sport?
Yes under WADA rules. The 2026 Prohibited List explicitly names CJC-1295 among growth hormone-releasing hormone analogues in section S2.2.4, which is prohibited at all times.
Why should CJC-1295 products be separated by DAC status?
Because the DAC modification changes the molecule and its exposure profile. The multi-day human half-life data belong to the DAC form, so mixing DAC and no-DAC products without a clear label would make the comparison scientifically misleading.