Compare the declared formulation first, then the label daily amount. A phytosome ingredient, standardised extract and berberine HCl can carry different milligram meanings, so each amount is shown with its basis and forms are never converted into one another. The amount is what the label states; it is not a dose-adequacy rating. Where directions give a range, the range is shown and daily cost uses the low end (no directions: one unit a day). Read the dose guide ↓

Berberine product comparison
#	Product	Berberine form	Daily dose	Price/day	Testing	Score
1	Sports Research Berberine HCl 1000mg – 120 CapsulesSports Research120 capsules	Berberine HClCapsuleNot stated	1,000 mgWithin typical rangeTypical: 900–1,500 mg/day	$0.53per day$31.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Sports Research product page says the berberine capsules are "third-party tested" and "Non-GMO Verified, Vegan Certified, Gluten-Free"; the Amazon listing image also says "Third Party Tested" and shows Non-GMO Project Verified / Vegan Action logos. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:23:15 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 22/25 Value 18/20 Dose transparency 15/15 Manufacturer transparency 6/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
2	Doctors’ Preferred Berberine HCl 500mg – 90 CapsulesDoctors’ Preferred90 capsules	Berberine HClCapsuleNot stated · BerberPure	1,500 mgWithin typical rangeTypical: 900–1,500 mg/day	$0.95per day$28.54 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing image/text says: "Doctor formulated and independently tested for optimal purity and potency" and the bottle image says "UNCONDITIONALLY GUARANTEED for purity and labeled potency." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:14:20	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 23/25 Value 13/20 Dose transparency 15/15 Manufacturer transparency 9/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
3	Natural Factors Berberine HCl 1000mg – 120 CapsulesNatural Factors120 capsules	Berberine HClCapsuleNot stated	1,000 mgWithin typical rangeTypical: 900–1,500 mg/day	$0.58per day$34.97 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Natural Factors says on its product page that it is "Third-Party Certified" and shows the ISURA seal; Natural Factors also states "The ISURA seal of approval on a Natural Factors product means it has been rigorously verified" and that ISURA tests for contaminants and label integrity. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:25:08 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 22/25 Value 17/20 Dose transparency 15/15 Manufacturer transparency 6/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
4	Nutricost Berberine HCl 1200mg – 60 CapsulesNutricost60 capsules	Berberine HClCapsuleNot stated	1,200 mgWithin typical rangeTypical: 900–1,500 mg/day	$0.63per day$18.89 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Nutricost product page states: "3rd Party Tested by ISO-Accredited Laboratoreis" and "Nutricost products are tested by an independent, accredited lab to help verify that what’s on the label is what’s in the bottle." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:34:32 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 22/25 Value 16/20 Dose transparency 15/15 Manufacturer transparency 6/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
5	NOW Berberine HCl 400mg – 90 SoftgelsNOW90 softgels	Berberine HClSoftgelNot stated	1,200 mgWithin typical rangeTypical: 900–1,500 mg/day	$0.73per day$21.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement NOW’s product page says: “Made and quality tested in the USA with globally sourced ingredients.” The Amazon listing also says: “NOW Foods regularly tests its berberine capsules in independent laboratories to ensure quality and purity.” Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:32:36 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 22/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 6/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
6	Smart Nutra Labs Berberine HCl 1200mg – 180 CapsulesSmart Nutra Labs180 capsules	Berberine HClCapsuleNot stated	1,200 mgWithin typical rangeTypical: 900–1,500 mg/day	$0.40per day$35.99 per packBuy Nowon Amazon	Testing evidence Evidence status No public evidence located Manufacturer statement Not recorded Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:12:34	Why this score? Testing & evidence 4/20 Ingredient/formulation quality 21/25 Value 18/20 Dose transparency 15/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
7	Luma Nutrition Berberine HCl 1200mg – 60 CapsulesLuma Nutrition60 capsules	Berberine HClCapsuleNot stated	1,200 mgWithin typical rangeTypical: 900–1,500 mg/day	$1.00per day$29.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing says: "Third Party Tested 🔬 Independently tested to verify purity and quality. Every batch is checked to meet high manufacturing standards for confidence and transparency." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:33:37 Amazon listing (claim source) ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 22/25 Value 12/20 Dose transparency 15/15 Manufacturer transparency 7/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
8	Nature Made Berberine Phytosome 550mg – 60 CapsulesNature Made60 capsules	Berberine PhytosomeCapsuleNot stated · Berbevis	1,100 mg	$1.05per day$31.62 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Wellgard’s About Us page says: “The Gold Standard means: Ingredients you can trust - always high-quality and third-party tested.” This is a general brand claim, but I did not find an independently verifiable COA, lab report, or certifying-body registry entry for this specific Berbenite product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:15:58 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 21/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
9	NutriVein Berberine Extract 10:1 – 120 CapsulesNutriVein120 capsules	Standardised extractCapsule10:1 extract · Not stated	1,200 mg	$0.44per day$26.35 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Nutrivein’s product page says: “Our finished products are further tested and certified by a third-party lab for quality, purity, and potency.” The Amazon listing also shows a “Third-Party Tested” badge, but I did not find an independently verifiable lab report or registry entry for this specific berberine product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:20:07 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 20/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
10	New Chapter Berberine HCl 1000mg – 60 CapsulesNew Chapter60 capsules	Berberine HClCapsule30:1 extract · Not stated	1,000 mgWithin typical rangeTypical: 900–1,500 mg/day	$1.00per day$29.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement New Chapter’s product page says: “For every product lot we ship, we test for all four metals…” and the berberine product page says its ingredients are in accordance with strict safety and purity requirements and “Meets strict requirements for: ✓ Organoleptic Identity ✓ Appearance ✓ Vitamin/Mineral Assay ✓ Pesticides ✓ Gluten ✓ Allergens ✓ Heavy Metals ✓ Microbiological Attributes.” Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:11:04 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 22/25 Value 12/20 Dose transparency 15/15 Manufacturer transparency 4/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
11	Himalaya Berberine HCl 1000mg – 60 CapsulesHimalaya60 capsules	Berberine HClCapsuleNot stated	1,000 mgWithin typical rangeTypical: 900–1,500 mg/day	$0.85per day$25.49 per packBuy Nowon Amazon	Testing evidence Evidence status No public evidence located Manufacturer statement Not recorded Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:10:24	Why this score? Testing & evidence 4/20 Ingredient/formulation quality 22/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 4/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
12	Metagenics Berberine HCl 500mg – 60 CapsulesMetagenics60 capsules	Berberine HClCapsuleNot stated	1,000–1,500 mgWithin typical rangeTypical: 900–1,500 mg/day	$1.50per day$44.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Metagenics’ quality page says: “Our products undergo rigorous testing for heavy metals, microbial contaminants, pesticides, and more” and “every ingredient and finished product undergoes rigorous testing to ensure it meets our uncompromising standards.” The Berberine GT Amazon images also say “3rd party tested” and “Guaranteed purity,” but I did not find an independently verifiable COA, lab report, or certifying-body registry entry for this specific product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:22:35 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 22/25 Value 9/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
13	Thorne Berberine HCl 200mg – 60 CapsulesThorne60 capsules	Berberine HClCapsuleNot stated	400–600 mgBelow typical rangeTypical: 900–1,500 mg/day	$1.00per day$30.00 per packBuy Nowon Amazon	Testing evidence Evidence status Recognised certification Manufacturer statement Thorne’s product page says: “This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants, such as heavy metals, pesticides, and microorganisms.” NSF’s own listings page for Thorne shows NSF/ANSI Standard 173 dietary supplement certification for Thorne products, and Thorne’s NSF article says NSF is the independent certifier for Thorne supplements. Laboratory Not recorded Certification body NSF Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:31:46 Certification record ↗ Manufacturer testing page ↗	Why this score? Testing & evidence 20/20 Ingredient/formulation quality 19/25 Value 8/20 Dose transparency 5/15 Manufacturer transparency 6/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
14	Toniiq Berberine HCl 500mg – 90 CapsulesToniiq90 capsules	Not disclosedCapsule	Amount not stated	$0.30per day$26.97 per packBuy Nowon Amazon	Testing evidence Evidence status Verified independent evidence Manufacturer statement Toniiq product page states: "Certificate of Analysis & Testing" and "Every Toniiq product lot is third-party tested for: Microbiology and Presence of Heavy Metals in Raw Material; Assay of Active Ingredient in Raw Material; Assay of Active Ingredient in Finished Product; Fill Weight in Finished Product; Microbiology and Presence of Heavy Metals in Finished Product." Laboratory Certified Group - Tustin Certification body Not recorded Batch 25-631139 / Lot # 25K0291 Batch-specific report Recorded Report date Not recorded Evidence checked 2026-09-27 13:28:53 Certificate of analysis ↗ Laboratory report ↗ Manufacturer testing page ↗	Why this score? Testing & evidence 20/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 6/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
15	Double Wood Supplements Berberine HCl 500mg – 60 CapsulesDouble Wood Supplements60 capsules	Not disclosedCapsule	Amount not stated	$0.32per day$18.95 per packBuy Nowon Amazon	Testing evidence Evidence status Manufacturer COA Manufacturer statement Manufacturer page states: "Double Wood's formula delivers 500mg of berberine HCl per capsule, verified by HPLC ... on every batch ... Our most recent COA confirmed not less than 500mg berberine HCl per capsule, tested by a PJLA-accredited ISO/IEC 17025:2017 laboratory. Every batch tested for purity, potency, heavy metals, and microbial safety." Laboratory PJLA-accredited ISO/IEC 17025:2017 laboratory (lab name not shown in the readable PDF text) Certification body Not recorded Batch 2429001 Batch-specific report Recorded Report date Not recorded Evidence checked 2026-09-27 13:27:46 Certificate of analysis ↗ Laboratory report ↗ Manufacturer testing page ↗	Why this score? Testing & evidence 16/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 6/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
16	Integrative Therapeutics Berberine HCl 500mg – 60 CapsulesIntegrative Therapeutics60 capsules	Berberine HClCapsuleNot stated	1,000–1,500 mgWithin typical rangeTypical: 900–1,500 mg/day	$1.09per day$32.75 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Manufacturer quality page says: "Methodically testing of every raw material lot to ensure purity and potency" and "Testing finished goods to make sure they meet our label and shelf-life expectations." Amazon listing also says "Third-Party Tested." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:35:16 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 21/25 Value 10/20 Dose transparency 11/15 Manufacturer transparency 4/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
17	NatureBell Berberine HCl 500mg – 300 CapsulesNatureBell300 capsules	Not disclosedCapsule	Amount not stated	$0.18per day$26.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement NatureBell’s product page says: “Made with non-GMO ingredients and produced in a cGMP-compliant facility. Third-party lab tested and made without gluten, soy, and dairy.” Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:30:26 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
18	NOW Berberine HCl 500mg – 90 CapsulesNOW90 capsules	Berberine HClCapsuleNot stated	500 mgBelow typical rangeTypical: 900–1,500 mg/day	$0.25per day$22.69 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement NOW’s own product page says: “Made and quality tested in the USA with globally sourced ingredients.” NOW’s berberine testing article also says it tested over thirty berberine supplements and that NOW’s sample was tested by NOW’s in-house lab and Alkemist Labs, but the article does not provide a product-specific certificate/registry entry for this 90-capsule product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:26:53 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 19/25 Value 14/20 Dose transparency 0/15 Manufacturer transparency 9/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
19	Nutreb Berberine HCl 1200mg – 60 CapsulesNutreb60 capsules	Not disclosedCapsule	Amount not stated	$1.00per day$29.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Nutreb’s own page says: “Lab tested in the USA” and “Nutreb Berberine has undergone rigorous clinical testing in the USA and has been proven safe and effective.” Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:21:33 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
20	Designs for Health Berberine HCl 400mg – 60 CapsulesDesigns for Health60 capsules	Berberine HClCapsuleNot stated	400 mgBelow typical rangeTypical: 900–1,500 mg/day	$0.89per day$53.49 per packBuy Nowon Amazon	Testing evidence Evidence status Manufacturer COA Manufacturer statement Designs for Health’s COA page states: “We test every batch of our products… Each Certificate of Analysis (COA) confirms that your product has been third-party tested and verified.” The Berberine Synergy COA PDF shows Item #: BER060-7A, Lot # 2605359, and results of 400mg and 50mg by HPLC with microbial testing, marked “**Denotes 3rd party testing.” Laboratory Not recorded Certification body Not recorded Batch 2605359 Batch-specific report Recorded Report date Not recorded Evidence checked 2026-09-27 13:24:24 Certificate of analysis ↗ Laboratory report ↗ Manufacturer testing page ↗	Why this score? Testing & evidence 16/20 Ingredient/formulation quality 18/25 Value 9/20 Dose transparency 0/15 Manufacturer transparency 4/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
21	Solaray Berberine HCl 500mg – 100 CapsulesSolaray100 capsules	Berberine HClCapsuleNot stated	500 mgBelow typical rangeTypical: 900–1,500 mg/day	$0.39per day$39.49 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Solaray’s product page says: “A targeted blood glucose support formula featuring Non-GMO Project Verified berberine from Indian barberry root… produced in our GMP facility that is certified by NSF, with ingredients that are triple-tested to meet strict guidelines on potency, purity, and contaminants.” Solaray’s quality page also says: “In our Ogden, Utah lab, scientists conduct up to 15,000 scientific tests each month… we confirm identity, potency, and purity, and screen for contaminants like heavy metals and pesticides.” Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:18:59 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 19/25 Value 14/20 Dose transparency 0/15 Manufacturer transparency 6/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
22	JSHealth Berberine Phytosome 550mg – 60 CapsulesJSHealth60 capsules	Not disclosedCapsule	Amount not stated	$1.67per day$49.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Manufacturer page states: "Heavy Metal Tested + Quality Formula" on the Berberine+ Formula product page, but I did not find an independently verifiable COA, lab report, or third-party certification for this specific product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:26:18 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 4/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
23	Enzymedica Berberine Phytosome 275mg – 60 CapsulesEnzymedica60 capsules	Not disclosedCapsule	Amount not stated	$0.31per day$18.56 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Enzymedica’s ‘Behind The Science’ page says: ‘Our products and ingredients are tested by certified third-party laboratories. We not only ensure what is on the label is what’s in the bottle, but we also test for residues and contaminants.’ Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:13:29 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 7/15 Manufacturer transparency 7/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
24	Solaray Berberine Phytosome 550mg – 30 CapsulesSolaray30 capsules	Not disclosedCapsule	Amount not stated	$0.77per day$22.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing and Solaray product page use marketing/testing language such as “Lab Verified,” “clinically studied,” and Solaray’s quality page says it tests identity, potency, and purity in-house; however I did not find an independently verifiable third-party COA or registry entry for this specific product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:17:02 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 7/15 Manufacturer transparency 6/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
25	Pure Encapsulations Berberine Phytosome 550mg – 60 CapsulesPure Encapsulations60 capsules	Not disclosedCapsule	Amount not stated	$0.86per day$51.50 per packBuy Nowon Amazon	Testing evidence Evidence status No public evidence located Manufacturer statement Not recorded Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 13:31:06	Why this score? Testing & evidence 4/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 6/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 1,000 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 2 veggie capsules
Servings/day: 1
Pack size: 120 capsules

Full ingredients and formulation →

$0.53per day$31.95 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated · BerberPure
Daily dose: 1,500 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 3
Pack size: 90 capsules

Full ingredients and formulation →

$0.95per day$28.54 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 1,000 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 120 capsules

Full ingredients and formulation →

$0.58per day$34.97 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 1,200 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

$0.63per day$18.89 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClSoftgelNot stated
Daily dose: 1,200 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Softgel
Serving: 1 softgel
Servings/day: 3
Pack size: 90 softgels

Full ingredients and formulation →

$0.73per day$21.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 1,200 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 180 capsules

Full ingredients and formulation →

$0.40per day$35.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 1,200 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

$1.00per day$29.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine PhytosomeCapsuleNot stated · Berbevis
Daily dose: 1,100 mg

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 2
Pack size: 60 capsules

Full ingredients and formulation →

$1.05per day$31.62 per pack

View Analysis Buy Now on Amazon

Berberine form: Standardised extractCapsule10:1 extract · Not stated
Daily dose: 1,200 mg

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 120 capsules

Full ingredients and formulation →

$0.44per day$26.35 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsule30:1 extract · Not stated
Daily dose: 1,000 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 2 tablets
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

$1.00per day$29.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 1,000 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

$0.85per day$25.49 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 1,000–1,500 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 60 capsules

Full ingredients and formulation →

$1.50per day$44.95 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 400–600 mgBelow typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 60 capsules

Full ingredients and formulation →

$1.00per day$30.00 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 vegetarian capsule
Servings/day: Not disclosed
Pack size: 90 capsules

Full ingredients and formulation →

$0.30per day$26.97 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

$0.32per day$18.95 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 1,000–1,500 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 60 capsules

Full ingredients and formulation →

$1.09per day$32.75 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 2 vegetarian capsules
Servings/day: 1
Pack size: 300 capsules

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$0.18per day$26.99 per pack

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Berberine form: Berberine HClCapsuleNot stated
Daily dose: 500 mgBelow typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 veg capsule
Servings/day: Not disclosed
Pack size: 90 capsules

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$0.25per day$22.69 per pack

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Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: Not disclosed
Pack size: 60 capsules

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$1.00per day$29.95 per pack

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Berberine form: Berberine HClCapsuleNot stated
Daily dose: 400 mgBelow typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 60 capsules

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$0.89per day$53.49 per pack

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Berberine form: Berberine HClCapsuleNot stated
Daily dose: 500 mgBelow typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 VegCap
Servings/day: Not disclosed
Pack size: 100 capsules

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$0.39per day$39.49 per pack

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Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 60 capsules

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$1.67per day$49.99 per pack

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Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 60 capsules

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$0.31per day$18.56 per pack

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Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 VegCap
Servings/day: Not disclosed
Pack size: 30 capsules

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$0.77per day$22.99 per pack

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Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 60 capsules

Full ingredients and formulation →

$0.86per day$51.50 per pack

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One-time purchase prices; delivery and conditional discounts excluded. Daily cost uses the recorded label serving. Comparison amounts are not personal dose recommendations. Unknown Prime eligibility is not treated as confirmed.

Berberine forms and labels explained

Berberine labels can describe a salt, a botanical extract, a branded delivery system or a related derivative. Keep the declared basis visible before comparing milligrams.

Berberine HCl

Conventional salt form

Compare: Declared HCl amount
Do not assume: Free-base equivalence

Common in supplements and clinical studies. Keep the label-declared salt basis unless a verified source provides an active-equivalent amount.

Standardised botanical extract

Plant extract with an assay claim

Check: Extract mass and {3683f0b818e4e7eac3a25ad8212965194ab09621a23bd0189e97e17dfedff11f} berberine
Best basis: Explicitly declared berberine

A large extract number is not automatically the amount of berberine. Record both when disclosed.

Berberine Phytosome

Enhanced-delivery formulation

Check: Exact branded ingredient
Do not convert: Ingredient mg to HCl mg

Absorption evidence is formulation-specific. Ingredient-system milligrams are not interchangeable with conventional berberine milligrams.

Dihydroberberine

Related reduced derivative

Evidence: Small human PK studies
Comparison: Separate formulation class

Higher exposure in small pharmacokinetic studies does not establish clinical dose equivalence, efficacy or long-term safety.

Berberine amounts: labels, studies and what they mean

There is no U.S. Daily Value, RDA or AI established for berberine in the reviewed federal sources. FDA guidance says dietary ingredients without an established Daily Value are labeled as “Daily Value Not Established.” [3]

Clinical trials have often used conventional berberine at roughly 0.9–1.5 g/day for about one to three months, but these are studied amounts, not a universal recommendation or safety ceiling. [4] [5]

Use each product’s declared daily serving. Do not convert a salt, standardised extract, phytosome ingredient or dihydroberberine dose into an “equivalent” berberine dose unless a reliable source gives that exact conversion.

What the human evidence shows

Randomised-trial syntheses suggest berberine can produce modest changes in some glucose and lipid markers, particularly fasting glucose, triglycerides and LDL cholesterol, in studied populations. However, the evidence is heterogeneous, many trials are short, and much of the literature comes from Asian populations. [4] [5]

This does not establish berberine as a replacement for prescribed treatment or prove that every commercial formulation has the same effect.

Berberine evidence by goal

Evidence by goal
Goal	Evidence strength	What was assessed	Typical study context	Main limitation
Blood sugar markers	Promising but limited	Mostly conventional/purified berberine	Randomised-trial syntheses commonly include about 0.9–1.5 g/day for one to three months in adults with diabetes or metabolic risk.	Short trials, heterogeneous methods and populations; some analyses include background medicines.
LDL cholesterol and triglycerides	Moderate short-term evidence for small changes	Mostly conventional/purified berberine	Placebo-controlled RCT meta-analysis reports modest average reductions in LDL-C and triglycerides.	No proof of reduced cardiovascular events; substantial heterogeneity and mostly short follow-up.
Weight loss	Insufficient for a firm claim	Mixed berberine preparations and populations	Reviews report small average changes in some body-size measures, often in people with metabolic conditions.	Bias, inconsistent findings, varied formulations and limited general-population evidence.
Enhanced absorption	Formulation-specific pharmacokinetic evidence	Dihydroberberine and branded phytosome systems	Small human PK studies and manufacturer formulation studies assess blood exposure.	PK differences do not prove equal clinical benefits at lower milligram doses.

Read the full evidence-by-goal detail

Blood sugar and insulin-related markers

Meta-analyses of randomised trials report reductions in fasting and post-meal glucose in some studied groups, including people with type 2 diabetes or metabolic risk. Study quality, co-treatment and population differences limit how broadly the results can be applied. [5]

Cholesterol and triglycerides

Placebo-controlled evidence suggests modest reductions in LDL cholesterol, total cholesterol and triglycerides. The available trials are generally short and do not show that berberine prevents heart attacks or other clinical events. [4]

Weight and body composition

Weight-loss evidence is less certain than the marketing often suggests. NCCIH notes that studies vary in dose, formulation and participant health status and that higher-quality research is needed before firm conclusions can be drawn. [2]

When berberine is taken

There is no single proven best time of day for every berberine formulation. Study protocols and commercial labels vary. Some labels direct use with food, while others simply specify a daily serving. Follow the exact product directions rather than assuming morning, night or pre-meal dosing is universally better.

If the label gives a range of servings per day, the comparison should show that range instead of silently choosing one value.

Side effects, medicines and who should be cautious

Who should be cautious?If any of the following apply to you, speak to a healthcare professional before taking Berberine - see the full detail below for why.

People who are pregnant, trying to conceive or breastfeeding
Infants and children; this comparison is adult-only
People taking prescription medicines because berberine can affect drug-metabolising pathways
People using glucose-lowering treatment or managing a diagnosed metabolic condition without clinician/pharmacist review

Berberine can cause gastrointestinal effects such as nausea, abdominal discomfort, constipation or diarrhoea in clinical studies. It can also interact with medicines. In a human crossover study, repeated berberine dosing altered CYP2D6, CYP2C9 and CYP3A4 activity. [6]

NCCIH advises that berberine should not be used during pregnancy or breastfeeding and should not be given to infants. [1] People taking medicines should ask a pharmacist or clinician before using berberine rather than relying on a general interaction list.

Berberine blends and combination products

Combination products should not receive credit for effects that cannot be separated from their other ingredients. Record berberine and each additional active ingredient separately. If a product combines conventional berberine with an enhanced-absorption ingredient, keep both declared amounts and bases rather than adding them into one “total berberine” number unless the manufacturer supplies a verified active-equivalent calculation.

Who looks at berberine supplements

Berberine products are mainly marketed to adults interested in metabolic-health, blood-sugar, cholesterol or weight-related claims. The comparison page should present the evidence behind those claims without turning them into personal recommendations. People who are pregnant or breastfeeding, people taking medicines, and people managing diagnosed conditions should seek individual professional advice before use. [7] [6]

How to check berberine quality and testing

Useful testing evidence for berberine includes identity of the botanical or chemical ingredient, a quantitative assay for berberine, and contaminant testing where relevant. For standardised extracts or branded delivery systems, the report should identify the exact ingredient and batch. A GMP badge or a general “third-party tested” statement does not by itself prove the declared berberine amount in the bottle.

Enhanced-absorption claims must be tied to the exact studied formulation. Berbevis® has formulation-specific manufacturer pharmacokinetic material, while dihydroberberine has small human pharmacokinetic studies; neither justifies treating every product using similar marketing language as equivalent. [9] [8]

Testing evidence in this comparison

A testing claim is not the same as a verified report. No public evidence located does not mean a product has not been tested.

Testing review pending0

Recognised certification1

Verified independent evidence1

Manufacturer COA2

Testing claimed18

No public evidence located3

What does berberine cost?

Current US comparison set, based on the daily serving shown on each label.

$0.25Lowest daily cost

$0.85Median daily cost

$1.50Highest daily cost

Your questions, answered

What is berberine?

Berberine is a plant alkaloid found in several botanicals, including Berberis species. Supplements may provide it as berberine HCl, a standardised extract or a specialised delivery formulation. Those labels are not automatically equivalent.

How much berberine should I take?

There is no official U.S. Daily Value or universal recommended berberine dose. Trials often use roughly 0.9–1.5 g/day of conventional berberine for short periods, but that is research exposure, not personal advice or a safety limit. [4] [5]

Is berberine good for weight loss?

NCCIH says some studies suggest weight or BMI changes, but the evidence is not conclusive and many studies have limitations. [2]

What is the difference between berberine HCl and berberine phytosome?

Berberine HCl is a conventional salt form. A phytosome is a delivery formulation that combines berberine-containing material with other components intended to change absorption. Compare each on its declared basis; do not treat the same milligram number as equivalent across forms. [9]

Can berberine interact with medicines?

Yes. Human research shows repeated berberine dosing can alter several CYP drug-metabolising enzymes. If you take medicines, ask a pharmacist or clinician before using it. [6]

Should berberine be taken with food?

Some product labels direct use with food, but there is no single best timing rule established for every formulation. Follow the exact label for the product you are comparing.

Sources & methodology

Read our methodology and how we verify testing.

Page updated26 Sep 2026

Editorial reviewSources checked 2026-09-26; editorial preview

Product evidenceSee individual records

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Berberine forms and labels explained

Berberine HCl

Standardised botanical extract

Berberine Phytosome

Dihydroberberine

Berberine amounts: labels, studies and what they mean

What the human evidence shows

Berberine evidence by goal

Blood sugar and insulin-related markers

Cholesterol and triglycerides

Weight and body composition

When berberine is taken

Side effects, medicines and who should be cautious

Berberine blends and combination products

Who looks at berberine supplements

How to check berberine quality and testing

Testing evidence in this comparison

What does berberine cost?

Your questions, answered

Sources & methodology