Compare the declared formulation first, then the label daily amount. A phytosome ingredient, standardised extract and berberine HCl can carry different milligram meanings, so each amount is shown with its basis and forms are never converted into one another. The amount is what the label states; it is not a dose-adequacy rating. Where directions give a range, the range is shown and daily cost uses the low end (no directions: one unit a day). Read the dose guide ↓

Berberine product comparison
#	Product	Berberine form	Daily dose	Price/day	Testing	Score
1	Vegavero Berberine HCl 500mg – 90 CapsulesVegavero90 capsules	Berberine HClCapsuleNot stated	500–1,000 mgWithin typical rangeTypical: 900–1,500 mg/day	£0.29per day£25.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Vegavero states on its own site: "our products must undergo rigorous controls before we can even bring them to market" and "we have decided to have our finished products tested annually and entirely voluntarily in independent German laboratories"; the berberine product page also says "Lab tested" and "Laboratory tested for heavy metals and microbiological quality." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:50:39 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 22/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
2	Toniiq Berberine HCl 500mg – 90 CapsulesToniiq90 capsules	Not disclosedCapsule	Amount not stated	£0.28per day£24.97 per packBuy Nowon Amazon	Testing evidence Evidence status Verified independent evidence Manufacturer statement Toniiq product page says: "Certificate of Analysis & Testing" and "Every Toniiq product lot is third-party tested for..." The COA for Berberine also shows testing by Certified Group - Tustin. Laboratory Certified Group - Tustin Certification body Not recorded Batch 25K0291 Batch-specific report Recorded Report date Not recorded Evidence checked 2026-09-27 07:49:57 Certificate of analysis ↗ Laboratory report ↗ Manufacturer testing page ↗	Why this score? Testing & evidence 19/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
3	SuperBotanic Dihydroberberine 150mg – 60 CapsulesSuperBotanic60 capsules	Not disclosedCapsule	Amount not stated	£0.82per day£24.64 per packBuy Nowon Amazon	Testing evidence Evidence status Verified independent evidence Manufacturer statement Manufacturer page says: "All our products are tested to ensure the highest quality, click here to the Certificate Of Analysis: View PDF →" and the linked COA for Berberine Advanced shows Eurofins Food Testing UK Limited with batch code B060725. Laboratory Eurofins Food Testing UK Limited Certification body Not recorded Batch B060725 Batch-specific report Recorded Report date Not recorded Evidence checked 2026-09-27 07:55:27 Certificate of analysis ↗ Laboratory report ↗ Manufacturer testing page ↗	Why this score? Testing & evidence 19/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
4	BioHerbs Berberine HCl 10:1 extract – 90 CapsulesBioHerbs90 capsules	Berberine HClCapsule10:1 extract · Not stated	200 mg	£0.17per day£14.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement BioHerbs’ own site says the product is “3rd Party Tested” and “third-party verified for purity and potency,” and the product page/landing page also says “TESTED” and “99{3683f0b818e4e7eac3a25ad8212965194ab09621a23bd0189e97e17dfedff11f} pure HCL.” I did not find a public COA/lab report or an independent registry entry confirming this specific BioHerbs Berberine product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:12:45 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 20/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
5	Sacred Summit Berberine HCl 10:1 extract – 90 CapsulesSacred Summit90 capsules	Berberine HClCapsule10:1 extract · Not stated	500–1,500 mg	£0.14per day£12.74 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Manufacturer site page titled “Berberine Batch Testing” says: “Select your batch number below to see our latest batch test results” and “We are deeply committed to purity and safety, which is why every batch undergoes rigorous testing for authenticity, purity, heavy metals, and harmful bacteria.” However, the page shown did not provide a batch-specific COA or independently verifiable lab report for this berberine product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:10:17 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 20/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
6	ReBirth Wellness Berberine Extract 10:1 – 60 CapsulesReBirth Wellness60 capsules	Standardised extractCapsule10:1 extract · Not stated	50 mg	£0.10per day£5.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Manufacturer site says: "Every supplement is 3rd-party lab-tested in the UK to guarantee purity, potency, and compliance with the highest industry standards." Product page also says: "Every supplement is 3rd-party lab-tested in the UK to guarantee purity, potency, and compliance." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:49:01 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 19/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 8/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
7	Health Thru Nutrition Berberine HCl 500mg – 120 CapsulesHealth Thru Nutrition120 capsules	Berberine HClCapsuleNot stated	500 mgBelow typical rangeTypical: 900–1,500 mg/day	£0.22per day£26.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Manufacturer site says the product page is "3rd Party Tested" on Amazon and the HTN science page says "our products undergo strict testing to qualify purity and stability"; the product page also says "tested by the highest standard HPLC ... to ensure potency levels at a minimum of 100{3683f0b818e4e7eac3a25ad8212965194ab09621a23bd0189e97e17dfedff11f} of the label claim in every single capsule." I did not find a product-specific COA, independent lab report, or a certifying-body registry entry for this berberine product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:47:08 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 19/25 Value 14/20 Dose transparency 9/15 Manufacturer transparency 9/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
8	Mantrphil Berberine HCl 20:1 extract – 90 CapsulesMantrphil90 capsules	Berberine HClCapsule20:1 extract · Not stated	250 mg	£0.11per day£9.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing says: "INDEPENDENTLY TESTED FOR QUALITY: Each production batch undergoes third-party testing at an ISO/IEC 17025:2017 accredited Eurofins lab to ensure it meets established quality and regulatory benchmarks." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:07:53 Amazon listing (claim source) ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 19/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 8/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
9	Igennus Berberine Phytosome 550mg – 60 CapsulesIgennus60 capsules	Not disclosedCapsule	Amount not stated	£0.50per day£29.99 per packBuy Nowon Amazon	Testing evidence Evidence status Recognised certification Manufacturer statement Nutrasource registry page states: "IGEN™ Certified" and "This product has PASSED because it does not contain detectable amounts of genetically engineered GMO proteins and genes included in the IGEN™ testing panel." Laboratory Not recorded Certification body Nutrasource IGEN™ Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:53:09 Certification record ↗ Manufacturer testing page ↗	Why this score? Testing & evidence 20/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 7/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
10	Vegan Vitality Berberine Extract 10:1 – 60 CapsulesVegan Vitality60 capsules	Standardised extractCapsule10:1 extract · Not stated	150 mg	£0.17per day£9.99 per packBuy Nowon Amazon	Testing evidence Evidence status No public evidence located Manufacturer statement Not recorded Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:59:36	Why this score? Testing & evidence 4/20 Ingredient/formulation quality 20/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
11	Ambrosial Berberine HCl 500mg – 60 CapsulesAmbrosial60 capsules	Berberine HClCapsuleNot stated	500 mgBelow typical rangeTypical: 900–1,500 mg/day	£0.27per day£15.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing says the product is "GMP Certified" and "each batch is tested to ensure it meets high manufacturing standards"; the manufacturer site repeats only general quality/benefit marketing and does not provide a product-specific COA or independent certification page. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:46:03 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 18/25 Value 12/20 Dose transparency 9/15 Manufacturer transparency 9/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
12	Complete Detox Berberine HCl 25:1 extract – 120 CapsulesComplete Detox120 capsules	Berberine HClCapsule25:1 extract · Not stated	600 mg	£0.13per day£15.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Manufacturer site says: “Our supplements are meticulously tested to ensure they meet the highest standards of safety and efficacy” and the product page says “Quality & Manufacturing … manufactured in the United Kingdom in facilities operating under GMP-certified quality standards” / “This ensures each product meets high standards for purity, safety, and consistency.” Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:52:33 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 19/25 Value 15/20 Dose transparency 7/15 Manufacturer transparency 9/10 Label/ingredient transparency 7/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
13	Nuke Nutrition Berberine Extract 10:1 – 60 CapsulesNuke Nutrition60 capsules	Standardised extractCapsule10:1 extract · Not stated	50 mg	£0.12per day£6.99 per packBuy Nowon Amazon	Testing evidence Evidence status No public evidence located Manufacturer statement Not recorded Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:02:53	Why this score? Testing & evidence 4/20 Ingredient/formulation quality 19/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 8/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
14	BANDINI Berberine Extract 500mg – 180 CapsulesBANDINI180 capsules	Not disclosedCapsule	Amount not stated	£0.13per day£22.90 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing and Bandini product pages say "QUALITY TESTED" / "Certified Product" and that products are manufactured in a "certified laboratory, compliant with GMP, UNI EN ISO 9001:2015, and ISO 22000 standards." The product page also shows only manufacturer certification document links, not a product-specific third-party COA or registry entry. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:54:41 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
15	Applied Nutrition Berberine HCl 1000mg – 60 CapsulesApplied Nutrition60 capsules	Not disclosedCapsule	Amount not stated	£0.63per day£18.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Applied Nutrition product page says "TRUSTED AND TESTED INGREDIENTS" and "All ingredients evaluated, scrutinised & analysed" and includes a "Tested for Athletes" section, but I did not find an independently verifiable COA or registry entry for this specific berberine product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:58:29 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
16	WeightWorld Berberine Extract 500mg – 120 CapsulesWeightWorld120 capsules	Not disclosedCapsule	Amount not stated	£0.14per day£16.49 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement WeightWorld product page says: "9/9 TESTS PASSED", "3/3 CLAIMS VERIFIED", and "INDEPENDENTLY LAB-TESTED" / "SEE LAB RESULTS". The page also says "Third party tested" and "All our products undergo thorough research and testing before they hit the market." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:11:14 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 15/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
17	NOW Berberine HCl 400mg – 90 SoftgelsNOW90 softgels	Berberine HClSoftgelNot stated	400 mgBelow typical rangeTypical: 900–1,500 mg/day	£0.34per day£30.63 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing says "Lab-Tested"; NOW product page says "Made and quality tested in the USA with globally sourced ingredients" and NOW's testing article says "NOW tested over thirty Berberine supplements" and that NOW sent one unopened bottle to Alkemist Labs for independent report on the same products. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:48:03 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 18/25 Value 8/20 Dose transparency 9/15 Manufacturer transparency 9/10 Label/ingredient transparency 10/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
18	Zipvit Berberine HCl 25:1 extract – 120 CapsulesZipvit120 capsules	Not disclosedCapsule	Amount not stated	£0.08per day£9.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Zipvit product page says: "4/4 TESTS PASSED", "1/1 CLAIMS VERIFIED", and "INDEPENDENTLY LAB-TESTED" / "SEE LAB RESULTS". The page also says the product is "independently tested for heavy metals" on the Amazon listing text, but I did not find a readable lab report or certifying-body registry entry for this specific product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:01:25 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
19	Swiss Peak Berberine HCl 20:1 extract – 90 CapsulesSwiss Peak90 capsules	Not disclosedCapsule	Amount not stated	£0.17per day£14.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Manufacturer site says: "Fully regulated. Independently tested. Our Berberine Capsules are manufactured in the UK under FSA (Food Standards Agency) guidelines, with every batch independently lab-tested for purity and safety." It also says "Vegan, Non-GMO & Third-Party Tested" and "Third-party lab tested." Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:56:33 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
20	VitaBright Berberine HCl 500mg – 90 CapsulesVitaBright90 capsules	Not disclosedCapsule	Amount not stated	£0.21per day£18.95 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement VitaBright’s own product page says: “All our supplements undergo rigorous quality testing. We normally have every batch tested by an independent laboratory which issues third-party certification.” The berberine product page also says “Lab Tested” and “3rd Party Tested – Unbiased & Verified Results,” but I did not find an independently verifiable lab report or certifying-body registry entry for this specific product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:02:08 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
21	Nutrination Berberine HCl 20:1 extract – 90 CapsulesNutrination90 capsules	Not disclosedCapsule	Amount not stated	£0.11per day£9.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing says the product is 'Lab Tested' and 'Independently laboratory tested for quality and purity with batch-specific analytical testing.' The product images also state 'Every Batch is Tested to Meet UK & EU Supplement Standards' and show a Eurofins logo, but I did not find an independently verifiable registry entry or product-specific lab report for this NutriNation berberine product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:09:15 Amazon listing (claim source) ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
22	Wellgard Berberine HCl 350mg – 30 CapsulesWellgard30 capsules	Berberine HClCapsuleNot stated	350 mgBelow typical rangeTypical: 900–1,500 mg/day	£0.47per day£14.24 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Wellgard’s About Us page says: “Ingredients you can trust - always high-quality and third-party tested.” Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:06:11 Manufacturer testing page ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 17/25 Value 5/20 Dose transparency 8/15 Manufacturer transparency 7/10 Label/ingredient transparency 9/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
23	Pure Vitality Berberine Extract 10:1 – 90 CapsulesPure Vitality90 capsules	Not disclosedCapsule	Amount not stated	£0.11per day£9.99 per packBuy Nowon Amazon	Testing evidence Evidence status Testing claimed Manufacturer statement Amazon listing says the product is "independently tested for purity, quality, and safety you can trust" and the product images say "3rd Party Tested." The manufacturer's site I found only contains general marketing about purity, bioavailability, and science-backed formulations, not a verifiable lab report or certification page for this specific product. Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:04:11 Amazon listing (claim source) ↗	Why this score? Testing & evidence 9/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 7/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
24	Roundway Supplements Berberine HCl 20:1 extract – 60 CapsulesRoundway Supplements60 capsules	Not disclosedCapsule	Amount not stated	£0.50per day£14.99 per packBuy Nowon Amazon	Testing evidence Evidence status No public evidence located Manufacturer statement Not recorded Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 07:51:37	Why this score? Testing & evidence 4/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.
25	SMUG Supplements Berberine Extract 50:1 – 365 TabletsSMUG Supplements365 tablets	Not disclosedTablet	Amount not stated	£0.03per day£9.99 per packBuy Nowon Amazon	Testing evidence Evidence status No public evidence located Manufacturer statement Not recorded Laboratory Not recorded Certification body Not recorded Batch Not recorded Batch-specific report Not established in this record Report date Not recorded Evidence checked 2026-09-27 08:00:18	Why this score? Testing & evidence 4/20 Ingredient/formulation quality 16/25 Value 15/20 Dose transparency 11/15 Manufacturer transparency 9/10 Label/ingredient transparency 0/10 Displayed points and weights are rounded; the total uses unrounded weights. Pending dimensions are excluded. Provisional scores may change after review.

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 500–1,000 mgWithin typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 90 capsules

Full ingredients and formulation →

£0.29per day£25.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 90 capsules

Full ingredients and formulation →

£0.28per day£24.97 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 2
Pack size: 60 capsules

Full ingredients and formulation →

£0.82per day£24.64 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsule10:1 extract · Not stated
Daily dose: 200 mg

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 90 capsules

Full ingredients and formulation →

£0.17per day£14.95 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsule10:1 extract · Not stated
Daily dose: 500–1,500 mg

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 90 capsules

Full ingredients and formulation →

£0.14per day£12.74 per pack

View Analysis Buy Now on Amazon

Berberine form: Standardised extractCapsule10:1 extract · Not stated
Daily dose: 50 mg

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

£0.10per day£5.95 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 500 mgBelow typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 VegeCap
Servings/day: 1
Pack size: 120 capsules

Full ingredients and formulation →

£0.22per day£26.95 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsule20:1 extract · Not stated
Daily dose: 250 mg

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 90 capsules

Full ingredients and formulation →

£0.11per day£9.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 60 capsules

Full ingredients and formulation →

£0.50per day£29.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Standardised extractCapsule10:1 extract · Not stated
Daily dose: 150 mg

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

£0.17per day£9.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsuleNot stated
Daily dose: 500 mgBelow typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

£0.27per day£15.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClCapsule25:1 extract · Not stated
Daily dose: 600 mg

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 120 capsules

Full ingredients and formulation →

£0.13per day£15.95 per pack

View Analysis Buy Now on Amazon

Berberine form: Standardised extractCapsule10:1 extract · Not stated
Daily dose: 50 mg

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

£0.12per day£6.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 180 capsules

Full ingredients and formulation →

£0.13per day£22.90 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 60 capsules

Full ingredients and formulation →

£0.63per day£18.95 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 120 capsules

Full ingredients and formulation →

£0.14per day£16.49 per pack

View Analysis Buy Now on Amazon

Berberine form: Berberine HClSoftgelNot stated
Daily dose: 400 mgBelow typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Softgel
Serving: 1 softgel
Servings/day: 1
Pack size: 90 softgels

Full ingredients and formulation →

£0.34per day£30.63 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 120 capsules

Full ingredients and formulation →

£0.08per day£9.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 90 capsules

Full ingredients and formulation →

£0.17per day£14.99 per pack

View Analysis Buy Now on Amazon

Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 90 capsules

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£0.21per day£18.95 per pack

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Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 90 capsules

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£0.11per day£9.99 per pack

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Berberine form: Berberine HClCapsuleNot stated
Daily dose: 350 mgBelow typical rangeTypical: 900–1,500 mg/day

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: 1
Pack size: 30 capsules

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£0.47per day£14.24 per pack

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Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 1 capsule
Servings/day: Not disclosed
Pack size: 90 capsules

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£0.11per day£9.99 per pack

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Berberine form: Not disclosedCapsule
Daily dose: Amount not stated

Formulation & serving details

Format: Capsule
Serving: 2 capsules
Servings/day: 1
Pack size: 60 capsules

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£0.50per day£14.99 per pack

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Berberine form: Not disclosedTablet
Daily dose: Amount not stated

Formulation & serving details

Format: Tablet
Serving: 1 tablet
Servings/day: 1
Pack size: 365 tablets

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£0.03per day£9.99 per pack

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One-time purchase prices; delivery and conditional discounts excluded. Daily cost uses the recorded label serving. Comparison amounts are not personal dose recommendations. Unknown Prime eligibility is not treated as confirmed.

Berberine forms and labels explained

Berberine labels can describe a salt, a botanical extract, a branded delivery system or a related derivative. Keep the declared basis visible before comparing milligrams.

Berberine HCl

Conventional salt form

Compare: Declared HCl amount
Do not assume: Free-base equivalence

Common in supplements and clinical studies. Keep the label-declared salt basis unless a verified source provides an active-equivalent amount.

Standardised botanical extract

Plant extract with an assay claim

Check: Extract mass and {3683f0b818e4e7eac3a25ad8212965194ab09621a23bd0189e97e17dfedff11f} berberine
Best basis: Explicitly declared berberine

A large extract number is not automatically the amount of berberine. Record both when disclosed.

Berberine Phytosome

Enhanced-delivery formulation

Check: Exact branded ingredient
Do not convert: Ingredient mg to HCl mg

Absorption evidence is formulation-specific. Ingredient-system milligrams are not interchangeable with conventional berberine milligrams.

Dihydroberberine

Related reduced derivative

Evidence: Small human PK studies
Comparison: Separate formulation class

Higher exposure in small pharmacokinetic studies does not establish clinical dose equivalence, efficacy or long-term safety.

Berberine amounts: labels, studies and what they mean

There is no UK nutrient reference value or established tolerable upper intake level for berberine. UK reference-intake legislation lists NRVs for specified vitamins and minerals, not berberine. [2] The 2026 UK Committee on Toxicity discussion of EFSA’s draft safety assessment also recorded substantial uncertainties and did not establish a safe intake for the plant preparations under review. [4]

Clinical trials have often used conventional berberine at roughly 0.9–1.5 g/day for about one to three months, but these are studied amounts, not a universal recommendation or safety ceiling. [5] [6]

Use each product’s declared daily serving. Do not convert a salt, standardised extract, phytosome ingredient or dihydroberberine dose into an “equivalent” berberine dose unless a reliable source gives that exact conversion.

What the human evidence shows

Randomised-trial syntheses suggest berberine can produce modest changes in some glucose and lipid markers, particularly fasting glucose, triglycerides and LDL cholesterol, in studied populations. However, the evidence is heterogeneous, many trials are short, and much of the literature comes from Asian populations. [5] [6]

This does not establish berberine as a replacement for prescribed treatment or prove that every commercial formulation has the same effect.

Berberine evidence by goal

Evidence by goal
Goal	Evidence strength	What was assessed	Typical study context	Main limitation
Blood sugar markers	Promising but limited	Mostly conventional/purified berberine	Randomised-trial syntheses commonly include about 0.9–1.5 g/day for one to three months in adults with diabetes or metabolic risk.	Short trials, heterogeneous methods and populations; some analyses include background medicines.
LDL cholesterol and triglycerides	Moderate short-term evidence for small changes	Mostly conventional/purified berberine	Placebo-controlled RCT meta-analysis reports modest average reductions in LDL-C and triglycerides.	No proof of reduced cardiovascular events; substantial heterogeneity and mostly short follow-up.
Weight loss	Insufficient for a firm claim	Mixed berberine preparations and populations	Reviews report small average changes in some body-size measures, often in people with metabolic conditions.	Bias, inconsistent findings, varied formulations and limited general-population evidence.
Enhanced absorption	Formulation-specific pharmacokinetic evidence	Dihydroberberine and branded phytosome systems	Small human PK studies and manufacturer formulation studies assess blood exposure.	PK differences do not prove equal clinical benefits at lower milligram doses.

Read the full evidence-by-goal detail

Blood sugar and insulin-related markers

Meta-analyses of randomised trials report reductions in fasting and post-meal glucose in some studied groups, including people with type 2 diabetes or metabolic risk. Study quality, co-treatment and population differences limit how broadly the results can be applied. [6]

Cholesterol and triglycerides

Placebo-controlled evidence suggests modest reductions in LDL cholesterol, total cholesterol and triglycerides. The available trials are generally short and do not show that berberine prevents heart attacks or other clinical events. [5]

Weight and body composition

Some trials report small changes in BMI or waist circumference, but the evidence is not strong enough to treat berberine as a proven weight-loss treatment. The 2025 placebo-controlled meta-analysis found a small pooled BMI change and stressed the need for better trials. [5]

When berberine is taken

There is no single proven best time of day for every berberine formulation. Study protocols and commercial labels vary. Some labels direct use with food, while others simply specify a daily serving. Follow the exact product directions rather than assuming morning, night or pre-meal dosing is universally better.

If the label gives a range of servings per day, the comparison should show that range instead of silently choosing one value.

Side effects, medicines and who should be cautious

Who should be cautious?If any of the following apply to you, speak to a healthcare professional before taking Berberine - see the full detail below for why.

People who are pregnant, trying to conceive or breastfeeding
Infants and children; this comparison is adult-only
People taking prescription medicines because berberine can affect drug-metabolising pathways
People using glucose-lowering treatment or managing a diagnosed metabolic condition without clinician/pharmacist review

Berberine can cause gastrointestinal effects such as nausea, abdominal discomfort, constipation or diarrhoea in clinical studies. It can also interact with medicines. In a human crossover study, repeated berberine dosing altered CYP2D6, CYP2C9 and CYP3A4 activity. [7]

NHS guidance advises extra caution with herbal medicines in pregnancy or breastfeeding and when taking prescription medicines. [3] People taking medicines should ask a pharmacist or clinician before using berberine rather than relying on a general interaction list.

Berberine blends and combination products

Combination products should not receive credit for effects that cannot be separated from their other ingredients. Record berberine and each additional active ingredient separately. If a product combines conventional berberine with an enhanced-absorption ingredient, keep both declared amounts and bases rather than adding them into one “total berberine” number unless the manufacturer supplies a verified active-equivalent calculation.

Who looks at berberine supplements

Berberine products are mainly marketed to adults interested in metabolic-health, blood-sugar, cholesterol or weight-related claims. The comparison page should present the evidence behind those claims without turning them into personal recommendations. People who are pregnant or breastfeeding, people taking medicines, and people managing diagnosed conditions should seek individual professional advice before use. [8] [7]

How to check berberine quality and testing

Useful testing evidence for berberine includes identity of the botanical or chemical ingredient, a quantitative assay for berberine, and contaminant testing where relevant. For standardised extracts or branded delivery systems, the report should identify the exact ingredient and batch. A GMP badge or a general “third-party tested” statement does not by itself prove the declared berberine amount in the bottle.

Enhanced-absorption claims must be tied to the exact studied formulation. Berbevis® has formulation-specific manufacturer pharmacokinetic material, while dihydroberberine has small human pharmacokinetic studies; neither justifies treating every product using similar marketing language as equivalent. [10] [9]

Testing evidence in this comparison

A testing claim is not the same as a verified report. No public evidence located does not mean a product has not been tested.

Testing review pending0

Recognised certification1

Verified independent evidence2

Manufacturer COA0

Testing claimed18

No public evidence located4

What does berberine cost?

Current UK comparison set, based on the daily serving shown on each label.

£0.22Lowest daily cost

£0.29Median daily cost

£0.47Highest daily cost

Your questions, answered

What is berberine?

Berberine is a plant alkaloid found in several botanicals, including Berberis species. Supplements may provide it as berberine HCl, a standardised extract or a specialised delivery formulation. Those labels are not automatically equivalent.

How much berberine should I take?

There is no official UK NRV or universal recommended berberine dose. Trials often use roughly 0.9–1.5 g/day of conventional berberine for short periods, but that is research exposure, not personal advice or a safety limit. [5] [6]

Is berberine good for weight loss?

Evidence is not strong enough to call berberine a proven weight-loss treatment. Some studies report small changes in BMI or waist circumference, but study quality, populations and formulations vary. [5]

What is the difference between berberine HCl and berberine phytosome?

Berberine HCl is a conventional salt form. A phytosome is a delivery formulation that combines berberine-containing material with other components intended to change absorption. Compare each on its declared basis; do not treat the same milligram number as equivalent across forms. [10]

Can berberine interact with medicines?

Yes. Human research shows repeated berberine dosing can alter several CYP drug-metabolising enzymes. If you take medicines, ask a pharmacist or clinician before using it. [7]

Should berberine be taken with food?

Some product labels direct use with food, but there is no single best timing rule established for every formulation. Follow the exact label for the product you are comparing.

Sources & methodology

Read our methodology and how we verify testing.

Page updated26 Sep 2026

Editorial reviewSources checked 2026-09-26; editorial preview

Product evidenceSee individual records

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Berberine forms and labels explained

Berberine HCl

Standardised botanical extract

Berberine Phytosome

Dihydroberberine

Berberine amounts: labels, studies and what they mean

What the human evidence shows

Berberine evidence by goal

Blood sugar and insulin-related markers

Cholesterol and triglycerides

Weight and body composition

When berberine is taken

Side effects, medicines and who should be cautious

Berberine blends and combination products

Who looks at berberine supplements

How to check berberine quality and testing

Testing evidence in this comparison

What does berberine cost?

Your questions, answered

Sources & methodology